Early deprivation disruption of associative learning is a developmental pathway to depression and social problems.

ABSTRACT: Exposure to psychosocial deprivation is associated with elevations in numerous forms of impairment throughout the life-course. Disruptions in associative learning may be a key mechanism through which adversity, particularly psychosocial deprivation, increases risk for impairment. Existing data consistent with this claim come entirely from correlational studies. Here, we present the first experimental evidence relating psychosocial deprivation and disruptions in multiple forms of associative learning. Using data from the Bucharest Early Intervention Project, we demonstrate that randomized placement into a family caregiving environment during the infant/toddler period as compared to prolonged institutional care normalizes two forms of associative learning in early adolescence: reward respons

SUBMITTER: Sheridan MA 

PROVIDER: S-EPMC5992195 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature