Recent Findings in the Genetics of Blood Pressure: How to Apply in Practice or Is a Moonshot Required?

ABSTRACT:

Purpose of review

Hypertension is recognised as the biggest contributor to the global burden of disease, but it is controlled in less than a fifth of patients worldwide, despite being relatively easy to detect and the availability of inexpensive safe generic drugs. Blood pressure is regulated by a complex network of physiologic pathways with currently available drugs targeting key receptors or enzymes in the top pathways. Major advances in the dissection of both monogenic and polygenic determinants of blood pressure regulation and variation have not resulted in rapid translation of these discoveries into clinical applications or precision medicine.

Recent findings

Uromodulin is an example of a novel gene for hypertension identified from genome-wide association studies, curre

SUBMITTER: Padmanabhan S 

PROVIDER: S-EPMC5992231 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature