Patient-factors associated with metformin steady-state levels in type 2 diabetes mellitus with therapeutic dosage.

ABSTRACT:

Aims

This prospective study aimed to analyze metformin steady-state concentration in repeated constant dosage and the influencing patient-factors as well as to correlate them with glycemic control.

Methods

The validated HPLC-UV method was used to examine metformin steady-state concentration, while FBG and glycated albumin were used as the parameters of glycemic control during metformin administration.

Results

A total of 82 type-2 diabetes patients were involved with 32.1% of them having metformin Css^min and 84.1% having Css^max of metformin within the recommended therapeutic range. One patient had metformin Css that exceeded minimum toxic concentration despite his normal renal function and administered therapeutic dosage of metformin. Higher Css

SUBMITTER: Ningrum VDA 

PROVIDER: S-EPMC5992324 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature