A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder.

ABSTRACT:

Background

Attention-deficit/hyperactivity disorder (ADHD) shows substantial heritability and is two to seven times more common in male individuals than in female individuals. We examined two putative genetic mechanisms underlying this sex bias: sex-specific heterogeneity and higher burden of risk in female cases.

Methods

We analyzed genome-wide autosomal common variants from the Psychiatric Genomics Consortium and iPSYCH Project (n = 20,183 cases, n = 35,191 controls) and Swedish population register data (n = 77,905 cases, n = 1,874,637 population controls).

Results

Genetic correlation analyses using two methods suggested near complete sharing of common variant effects across sexes, with r_g estimates close to 1. Analyses of population data, however, indica

SUBMITTER: Martin J 

PROVIDER: S-EPMC5992329 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature