Significance of neurexin and neuroligin polymorphisms in regulating risk of Hirschsprung's disease.

ABSTRACT: By performing a basic case-control study among a Chinese population, the aims of this study were to explore if single nucleotide polymorphisms (SNPs) within neurexin and neuroligin were associated with susceptibility to Hirschsprung's disease (HD). Eleven SNPs within neurexin and neuroligin were selected in this basic case-control study, and this study recruited 210 children with HD and 187 healthy children. The t-test and Χ² test were used to find the difference between case and control in their clinical variables. OR and 95% CI were used to assess the association between HD susceptibility and neurexin/neuroligin polymorphisms/haplotypes. Several SNPs were significantly associated with altered risk of HD in the Chinese Han population, including rs1421589 within NRXN1, rs

SUBMITTER: Li Y 

PROVIDER: S-EPMC5992363 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature