Rosiglitazone and a β₃-Adrenoceptor Agonist Are Both Required for Functional Browning of White Adipocytes in Culture.

ABSTRACT: The recruitment of brite (or beige) adipocytes has been advocated as a means to combat obesity, due to their ability to phenotypically resemble brown adipocytes (BA). Lineage studies indicate that brite adipocytes are formed by differentiation of precursor cells or by direct conversion of existing white adipocytes, depending on the adipose depot examined. We have systematically compared the gene expression profile and a functional output (oxygen consumption) in mouse adipocytes cultured from two contrasting depots, namely interscapular brown adipose tissue, and inguinal white adipose tissue (iWAT), following treatment with a known browning agent, the peroxisome proliferator-activated receptor (PPARγ) activator rosiglitazone. Prototypical BA readily express uncoupling protein (UCP)1, and up

SUBMITTER: Merlin J 

PROVIDER: S-EPMC5992408 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature