Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys.

ABSTRACT: Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.

SUBMITTER: Abbink P 

PROVIDER: S-EPMC5992501 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature