Paternal use of antidepressants and offspring outcomes in Sweden: nationwide prospective cohort study.

ABSTRACT:

Objective

To examine the association between paternal antidepressant use at conception and offspring preterm birth, malformations, autism spectrum disorder, and intellectual disability.

Design

Observational prospective cohort study with regression methods, and negative control comparison.

Setting

Sweden nationwide.

Participants

170 508 children conceived from 29 July 2005 and born in 2006-07, followed up to 2014 at age 8-9 years. This cohort included 3983 children born to fathers receiving antidepressant treatment during the conception period (that is, from four weeks before conception to four weeks after), a control group of 164 492 children not exposed to paternal antidepressant use, and a negative control comparison group of 2033 children born to fathers who

SUBMITTER: Viktorin A 

PROVIDER: S-EPMC5992520 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature