Tolerance to paternal genotoxic damage promotes survival during embryo development in zebrafish (Danio rerio).

ABSTRACT: Spermatozoa carry DNA damage that must be repaired by the oocyte machinery upon fertilization. Different strategies could be adopted by different vertebrates to face the paternal genotoxic damage. Mammals have strong sperm selection mechanisms and activate a zygotic DNA damage response (DDR) (including cell cycle arrest, DNA repair and alternative apoptosis) in order to guarantee the genomic conformity of the reduced progeny. However, external fertilizers, with different reproductive strategies, seem to proceed distinctively. Previous results from our group showed a downregulation of apoptotic activity in trout embryos with a defective DNA repairing ability, suggesting that mechanisms of tolerance to damaged DNA could be activated in fish to maintain cell survival and to progress with deve

SUBMITTER: Fernandez-Diez C 

PROVIDER: S-EPMC5992526 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature