Feedback between tissue packing and neurogenesis in the zebrafish neural tube.

ABSTRACT: Balancing the rate of differentiation and proliferation in developing tissues is essential to produce organs of robust size and composition. Although many molecular regulators have been established, how these connect to physical and geometrical aspects of tissue architecture is poorly understood. Here, using high-resolution timelapse imaging, we find that changes to cell geometry associated with dense tissue packing play a significant role in regulating differentiation rate in the zebrafish neural tube. Specifically, progenitors that are displaced away from the apical surface due to crowding, tend to differentiate in a Notch-dependent manner. Using simulations we show that interplay between progenitor density, cell shape and changes in differentiation rate could naturally result in negativ

SUBMITTER: Hiscock TW 

PROVIDER: S-EPMC5992593 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature