Efficacy and tolerability of antidepressants in Parkinson's disease: A systematic review and network meta-analysis.

ABSTRACT:

Objective

To systematically review and analyze the efficacy and tolerability of different antidepressant pharmacologic treatments for depressive symptoms in Parkinson's disease (PD) METHODS: We searched PubMed, EMBASE, Cochrane database (CENTRAL), clinicaltrials.gov, and bibliographies for randomized controlled trials investigating the efficacy of antidepressant medications versus a non-treatment, placebo, or active treatment groups for depressive symptoms in PD. Twenty of 3191 retrieved studies (1893 patients) were included, but not all could be meta-analyzed. We used a random-effects model meta-analysis to compare depression scores between an active drug and placebo or control group then used a network meta-analysis to compare the effectiveness of different antidepressant classes

SUBMITTER: Mills KA 

PROVIDER: S-EPMC5992618 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature