Albumin mass balance and kinetics in liver transplantation.

ABSTRACT:

Background

In major abdominal surgery albumin is shifted from the circulation, presumably leaking into the interstitial space, contributing to a 30-40% decrease in plasma albumin concentration. During and after liver transplantation exogenous albumin is infused for volume substitution and to maintain plasma albumin concentration. Here we used liver transplantation as a model procedure for the study of albumin mass balance and kinetics during major abdominal surgery with albumin substitution.

Methods

Patients were studied during liver transplantation (n = 16), and until postoperative day 3 (POD 3) (n = 11). Cumulative perioperative albumin shift was assessed by mass balance of albumin and hemoglobin. Synthesis rates of albumin and fibrinogen were estimated by the flooding tec

SUBMITTER: Amouzandeh M 

PROVIDER: S-EPMC5992699 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature