Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.

ABSTRACT: Genomic characterization has begun to redefine diagnostic classifications of cancers. However, it remains a challenge to infer disease phenotypes from genomic alterations alone. To help realize the promise of genomics, we have performed a quantitative proteomics investigation using Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and 41 tissue samples spanning the 4 genomically based subgroups of medulloblastoma and control cerebellum. We have identified and quantitated thousands of proteins across these groups and find that we are able to recapitulate the genomic subgroups based upon subgroup restricted and differentially abundant proteins while also identifying subgroup specific protein isoforms. Integrating our proteomic measurements with genomic data, we calculate a poor

SUBMITTER: Rivero-Hinojosa S 

PROVIDER: S-EPMC5992829 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature