Description and characterization of a novel live-attenuated tri-segmented Machupo virus in Guinea pigs.

ABSTRACT:

Background

Machupo virus (MACV) is a member of the Mammarenavirus genus, Arenaviridae family and is the etiologic agent of Bolivian hemorrhagic fever, which causes small outbreaks or sporadic cases. Several other arenaviruses in South America Junín virus (JUNV) in Argentina, Guanarito in Venezuela, Sabiá in Brazil and Chapare in Bolivia, also are responsible for human hemorrhagic fevers. Among these arenaviruses, JUNV caused thousands of human cases until 1991, when the live attenuated Candid #1 vaccine, was used. Other than Candid #1 vaccine, few other therapeutic or prophylactic treatments exist. Therefore, new strategies for production of safe countermeasures with broad spectrum activity are needed.

Findings

We tested a tri-segmented MACV, a potential vaccine candidate wi

SUBMITTER: Zaza AD 

PROVIDER: S-EPMC5992841 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature