Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.

ABSTRACT:

Background

In recent years, human microbiota, especially gut microbiota, have emerged as an important yet complex trait influencing human metabolism, immunology, and diseases. Many studies are investigating the forces underlying the observed variation, including the human genetic variants that shape human microbiota. Several preliminary genome-wide association studies (GWAS) have been completed, but more are necessary to achieve a fuller picture.

Results

Here, we announce the MiBioGen consortium initiative, which has assembled 18 population-level cohorts and some 19,000 participants. Its aim is to generate new knowledge for the rapidly developing field of microbiota research. Each cohort has surveyed the gut microbiome via 16S rRNA sequencing and genotyped their participants

SUBMITTER: Wang J 

PROVIDER: S-EPMC5992867 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature