Family specific genetic predisposition to breast cancer: results from Tunisian whole exome sequenced breast cancer cases.

ABSTRACT:

Background

A family history of breast cancer has long been thought to indicate the presence of inherited genetic events that predispose to this disease. In North Africa, many specific epidemio-genetic characteristics have been observed in breast cancer families when compared to Western populations. Despite these specificities, the majority of breast cancer genetics studies performed in North Africa remain restricted to the investigation of the BRCA1 and BRCA2 genes. Thus, comprehensive data at a whole exome or whole genome level from local patients are lacking.

Methods

A whole exome sequencing (WES) of seven breast cancer Tunisian families have been performed using a family-based approach. We focused our analysis on BC-TN-F001 family that included two affected members that h

SUBMITTER: Hamdi Y 

PROVIDER: S-EPMC5992876 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature