Histologic and Optical Coherence Tomographic Correlates in Drusenoid Pigment Epithelium Detachment in Age-Related Macular Degeneration.

ABSTRACT:

Purpose

Drusenoid pigment epithelium detachment (DPED) is a known precursor to geographic atrophy in age-related macular degeneration (AMD). We sought histologic correlates for spectral-domain (SD) optical coherence tomography (OCT) signatures in DPED and determined the frequency and origin of these OCT signatures in a clinical cohort of DPED eyes.

Design

Laboratory imaging and histologic comparison, and retrospective, observational cohort study.

Participants

Four donor eyes with histopathologic diagnosis of AMD (2 with nonneovascular DPED and 2 with neovascular pigment epithelium detachment [PED]) and 49 eyes of 33 clinic patients with nonneovascular DPED more than 2 mm in diameter.

Methods

Donor eyes underwent multimodal ex vivo imaging, including SD OCT, the

SUBMITTER: Balaratnasingam C 

PROVIDER: S-EPMC5992891 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature