A "cross-stitched" peptide with improved helicity and proteolytic stability.

ABSTRACT: A new computational approach to obtain quantitative energy profiles for helix folding was used in the design of orthogonal hydrocarbon and lactam bicyclic peptides. The proteolytically stable, "cross-stitched" peptide SRC2-BCP1 shows nanomolar affinity for estrogen receptor α and X-ray crystallography confirms a helical binding pose.

SUBMITTER: Speltz TE 

PROVIDER: S-EPMC5993042 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature