Multicenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas.

ABSTRACT: Purpose Carboxyamidotriazole orotate (CTO) is a novel oral inhibitor of non-voltage-dependent calcium channels with modulatory effects in multiple cell-signaling pathways and synergistic effects with temozolomide (TMZ) in glioblastoma (GBM) models. We conducted a phase IB study combining CTO with two standard TMZ schedules in GBM. Methods In cohort 1, patients with recurrent anaplastic gliomas or GBM received escalating doses of CTO (219 to 812.5 mg/m² once daily or 600 mg fixed once-daily dose) combined with TMZ (150 mg/m² 5 days during each 28-day cycle). In cohort 2, patients with newly diagnosed GBM received escalating doses of CTO (219 to 481 mg/m²/d once daily) with radiotherapy and TMZ 75 mg/m²/d, followed by TMZ 150 mg to 200 mg/m^2</

SUBMITTER: Omuro A 

PROVIDER: S-EPMC5993168 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature