Mutation Signatures Including APOBEC in Cancer Cell Lines.

ABSTRACT:

Background

Multiple endogenous and exogenous sources of DNA damage contribute to the overall mutation burden in cancer, with distinct and overlapping combinations contributing to each cancer type. Many mutation sources result in characteristic mutation signatures, which can be deduced from tumor genomic DNA sequences. Examples include spontaneous hydrolytic deamination of methyl-cytosine bases in CG motifs (AGEING signature) and C-to-T and C-to-G mutations in 5'-TC(A/T) motifs (APOBEC signature).

Methods

The deconstructSigs R package was used to analyze single base substitution mutation signatures in over 1000 cancer cell lines. Two additional approaches were used to analyze the APOBEC mutation signature.

Results

Most cell lines show evidence for multiple mutation sig

SUBMITTER: Jarvis MC 

PROVIDER: S-EPMC5993214 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature