Androgen receptor positive triple negative breast cancer: Clinicopathologic, prognostic, and predictive features.

ABSTRACT:

Introduction

Overexpression of the androgen receptor (AR) characterizes a distinct molecular subset of triple negative breast carcinomas (TNBC). The role of AR as a prognostic/predictive biomarker in TNBC is controversial, but increasing evidence suggests that this subset may respond to therapeutic agents targeting AR. Evaluation of AR has not been standardized, and criteria for selection of patients for antiandrogen therapy remain controversial. In this study we determine the appropriate threshold of AR immunoreactivity to define AR positive (AR+) TNBC, describe the clinicopathologic features of AR+ TNBC, and discuss the utility of AR positivity as a prognostic and predictive marker in TNBC.

Materials and methods

135 invasive TNBC processed in accordance with ASCO/CAP guide

SUBMITTER: Astvatsaturyan K 

PROVIDER: S-EPMC5993259 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature