Resistome of carbapenem- and colistin-resistant Klebsiella pneumoniae clinical isolates.

ABSTRACT: The emergence and dissemination of carbapenemases, bacterial enzymes able to inactivate most β-lactam antibiotics, in Enterobacteriaceae is of increasing concern. The concurrent spread of resistance against colistin, an antibiotic of last resort, further compounds this challenge further. Whole-genome sequencing (WGS) can play a significant role in the rapid and accurate detection/characterization of existing and emergent resistance determinants, an essential aspect of public health surveillance and response activities to combat the spread of antimicrobial resistant bacteria. In the current study, WGS data was used to characterize the genomic content of antimicrobial resistance genes, including those encoding carbapenemases, in 10 multidrug-resistant Klebsiella pneumoniae isolates from Paki

SUBMITTER: Lomonaco S 

PROVIDER: S-EPMC5993281 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature