Synthesis, Radiolabelling and In Vitro Imaging of Multifunctional Nanoceramics.

ABSTRACT: Molecular imaging has become a powerful technique in preclinical and clinical research aiming towards the diagnosis of many diseases. In this work, we address the synthetic challenges in achieving lab-scale, batch-to-batch reproducible copper-64- and gallium-68-radiolabelled metal nanoparticles (MNPs) for cellular imaging purposes. Composite NPs incorporating magnetic iron oxide cores with luminescent quantum dots were simultaneously encapsulated within a thin silica shell, yielding water-dispersible, biocompatible and luminescent NPs. Scalable surface modification protocols to attach the radioisotopes ⁶⁴Cu (t_1/2=12.7 h) and ⁶⁸Ga (t_1/2=68 min) in high yields are reported, and are compatible with the time frame of radiolabelling. Confocal and fluo

SUBMITTER: Lledos M 

PROVIDER: S-EPMC5993288 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature