Vaccination-induced skin-resident memory CD8⁺ T cells mediate strong protection against cutaneous melanoma.

ABSTRACT: Memory CD8⁺ T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8⁺ T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens. Emerging evidence indicates that Trm cells develop in human solid cancers and play a key role in controlling tumor growth. However, the specific contribution of Trm cells to anti-tumor immunity is incompletely understood. Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors. Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell

SUBMITTER: Galvez-Cancino F 

PROVIDER: S-EPMC5993487 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature