Association of Hippocampal Substructure Resting-State Functional Connectivity with Memory Performance in Older Adults.

ABSTRACT: OBJECTIVES:Hippocampal hyperactivation marks preclinical dementia pathophysiology, potentially due to differences in the connectivity of specific medial temporal lobe structures. Our aims were to characterize the resting-state functional connectivity of medial temporal lobe sub-structures in older adults, and evaluate whether specific substructural (rather than global) functional connectivity relates to memory function. METHODS:In 15 adults (mean age: 69 years), we evaluated the resting state functional connectivity of medial temporal lobe substructures: dentate/Cornu Ammonis (CA) 4, CA1, CA2/3, subiculum, the molecular layer, entorhinal cortex, and parahippocampus. We used 7-Tesla susceptibility weighted imaging and magnetization-prepared rapid gradient echo sequences to segment substruct

SUBMITTER: Smagula SF 

PROVIDER: S-EPMC5993618 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature