Ontology highlight
ABSTRACT:
SUBMITTER: Caracciolo L
PROVIDER: S-EPMC5993731 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Nature communications 20180608 1
Treatments that stimulate neuronal excitability enhance motor performance after stroke. cAMP-response-element binding protein (CREB) is a transcription factor that plays a key role in neuronal excitability. Increasing the levels of CREB with a viral vector in a small pool of motor neurons enhances motor recovery after stroke, while blocking CREB signaling prevents stroke recovery. Silencing CREB-transfected neurons in the peri-infarct region with the hM4Di-DREADD blocks motor recovery. Reversing ...[more]