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Genome-wide association study identifies genes associated with neuropathy in patients with head and neck cancer.

ABSTRACT: Neuropathic pain (NP), defined as pain initiated or caused by a primary lesion or dysfunction in the nervous system, is a debilitating chronic pain condition often resulting from cancer treatment. Among cancer patients, neuropathy during cancer treatment is a predisposing event for NP. To identify genetic variants influencing the development of NP, we conducted a genome-wide association study in 1,043 patients with squamous cell carcinoma of the head and neck, based on 714,494 tagging single-nucleotide polymorphisms (SNPs) (130 cases, 913 controls). About 12.5% of the patients, who previously had cancer treatment, had neuropathy-associated diagnoses, as defined using the ICD-9/ICD-10 codes. We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10^-14), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10^-9), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10^-9) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10^-8), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer. Future experimental validation to explore physiological effects of the identified SNPs will provide a better understanding of the biological mechanisms underlying NP and may provide insights into novel therapeutic targets for treatment and management of NP.

SUBMITTER: Reyes-Gibby CC

PROVIDER: S-EPMC5993794 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Genome-wide association study identifies genes associated with neuropathy in patients with head and neck cancer.

Reyes-Gibby Cielito C CC Wang Jian J Yeung Sai-Ching J SJ Chaftari Patrick P Yu Robert K RK Hanna Ehab Y EY Shete Sanjay S

Scientific reports 20180608 1

Neuropathic pain (NP), defined as pain initiated or caused by a primary lesion or dysfunction in the nervous system, is a debilitating chronic pain condition often resulting from cancer treatment. Among cancer patients, neuropathy during cancer treatment is a predisposing event for NP. To identify genetic variants influencing the development of NP, we conducted a genome-wide association study in 1,043 patients with squamous cell carcinoma of the head and neck, based on 714,494 tagging single-nuc ...[more]

PMID: 29884837

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Dataset Information

Genome-wide association study identifies genes associated with neuropathy in patients with head and neck cancer.

Publications

Genome-wide association study identifies genes associated with neuropathy in patients with head and neck cancer.

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