Parametric mapping using spectral analysis for ¹¹C-PBR28 PET reveals neuroinflammation in mild cognitive impairment subjects.

ABSTRACT:

Purpose

Neuroinflammation and microglial activation play an important role in amnestic mild cognitive impairment (MCI) and Alzheimer's disease. In this study, we investigated the spatial distribution of neuroinflammation in MCI subjects, using spectral analysis (SA) to generate parametric maps and quantify ¹¹C-PBR28 PET, and compared these with compartmental and other kinetic models of quantification.

Methods

Thirteen MCI and nine healthy controls were enrolled in this study. Subjects underwent ¹¹C-PBR28 PET scans with arterial cannulation. Spectral analysis with an arterial plasma input function was used to generate ¹¹C-PBR28 parametric maps. These maps were then compared with regional ¹¹C-PBR28 V_T (volume of distributi

SUBMITTER: Fan Z 

PROVIDER: S-EPMC5993844 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature