Long-Term Correction of Diabetes in Mice by In Vivo Reprogramming of Pancreatic Ducts.

ABSTRACT: Direct lineage reprogramming can convert readily available cells in the body into desired cell types for cell replacement therapy. This is usually achieved through forced activation or repression of lineage-defining factors or pathways. In particular, reprogramming toward the pancreatic β cell fate has been of great interest in the search for new diabetes therapies. It has been suggested that cells from various endodermal lineages can be converted to β-like cells. However, it is unclear how closely induced cells resemble endogenous pancreatic β cells and whether different cell types have the same reprogramming potential. Here, we report in vivo reprogramming of pancreatic ductal cells through intra-ductal delivery of an adenoviral vector expressing the transcription factors Pdx1, Neurog3,

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5993989 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature