Identification of key genes in human airway epithelial cells in response to respiratory pathogens using microarray analysis.

ABSTRACT:

Background

Airway epithelium is the primary target for pathogens. It functions not only as a mechanical barrier, but also as an important sentinel of the innate immune system. However, the interactions and processes between host airway epithelium and pathogens are not fully understood.

Results

In this study, we identified responses of the human airway epithelium cells to respiratory pathogen infection. We retrieved three mRNA expression microarray datasets from the Gene Expression Omnibus database, and identified 116 differentially expressed genes common to all three datasets. Gene functional annotations were performed using Gene Ontology and pathway analyses. Using protein-protein interaction network analysis and text mining, we identified a subset of genes functioned as a

SUBMITTER: Li Y 

PROVIDER: S-EPMC5994059 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature