GSK3? Controls mTOR and Prosurvival Signaling in Neurons.

ABSTRACT: Glycogen synthase kinases-3? (GSK3?) is a key regulator of cell homeostasis. In neurons, GSK3? contributes to control of neuronal transmission and plasticity. Despite extensive studies in non-neuronal cells, crosstalk between GSK3? and other signaling pathways remains not well defined in neurons. In the present study, we report that GSK3? positively affected the activity of effectors of mammalian target of rapamycin complex 1 (mTORC1) and complex 2 (mTORC2), in mature neurons in vitro and in vivo. GSK3? also promoted prosurvival signaling and attenuated kainic acid-induced apoptosis. Our study identified GSK3? as a positive regulator of prosurvival signaling, including the mTOR pathway, and indicates the possible neuroprotective role of GSK3? in models of pharmacologically induced excitotoxicity.

SUBMITTER: Urbanska M 

PROVIDER: S-EPMC5994211 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature