Altered Salivary Alpha-Amylase Secretion in Patients with Ulcerative Colitis.

ABSTRACT:

Purpose

Patients with ulcerative colitis (UC) frequently present with psychological disturbances as well as dysfunctions of autonomic nervous system (ANS). Salivary alpha-amylase (sAA) secretion is predominantly controlled by sympathetic nervous activity, while salivary fluid secretion is by parasympathetic nervous activity. Thus, it is speculated that alterations of salivary secretion may be addressed in UC populations.

Methods

Thirty-five UC patients as well as 32 age- and sex-matched healthy controls were enrolled. Saliva samples before and after citric acid stimulation were collected from each participant, and salivary flow rate (SFR) was calculated accordingly. Western blotting and quantitative PCR were applied to measure the sAA level and sAA gene (AMY1) copy nu

SUBMITTER: Xu Z 

PROVIDER: S-EPMC5994290 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature