ERepo-ORP: Exploring the Opportunity Space to Combat Orphan Diseases with Existing Drugs.

ABSTRACT: About 7000 rare, or orphan, diseases affect more than 350 million people worldwide. Although these conditions collectively pose significant health care problems, drug companies seldom develop drugs for orphan diseases due to extremely limited individual markets. Consequently, developing new treatments for often life-threatening orphan diseases is primarily contingent on financial incentives from governments, special research grants, and private philanthropy. Computer-aided drug repositioning is a cheaper and faster alternative to traditional drug discovery offering a promising venue for orphan drug research. Here, we present eRepo-ORP, a comprehensive resource constructed by a large-scale repositioning of existing drugs to orphan diseases with a collection of structural bioinformatics tool

SUBMITTER: Brylinski M 

PROVIDER: S-EPMC5994353 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature