Randomized trial of transcranial alternating current stimulation for treatment of auditory hallucinations in schizophrenia.

ABSTRACT:

Background

Approximately 30% of patients with schizophrenia experience auditory hallucinations that are refractory to antipsychotic medications. Here, we evaluated the feasibility and efficacy of transcranial alternating current stimulation (tACS) that we hypothesized would improve auditory hallucination symptoms by enhancing synchronization between the frontal and temporo-parietal areas of the left hemisphere.

Method

22 participants were randomized to one of three arms and received twice daily, 20 min sessions of sham, 10 Hz 2 mA peak-to-peak tACS, or 2 mA tDCS over the course of 5 consecutive days. Symptom improvement was assessed using the Auditory Hallucination Rating Scale (AHRS) as the primary outcome measure. The Positive and Negative Syndrome Scale (PANSS) and the Br

SUBMITTER: Mellin JM 

PROVIDER: S-EPMC5994368 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature