Distinguishing allergens from non-allergenic homologues using Physical-Chemical Property (PCP) motifs.

ABSTRACT: Quantitative guidelines to distinguish allergenic proteins from related, but non-allergenic ones are urgently needed for regulatory agencies, biotech companies and physicians. In a previous study, we found that allergenic proteins populate a relatively small number of protein families, as characterized by the Pfam database. However, these families also contain non-allergenic proteins, meaning that allergenic determinants must lie within more discrete regions of the sequence. Thus, new methods are needed to discriminate allergenic proteins within those families. Physical-Chemical Properties (PCP)-motifs specific for allergens within a Pfam class were determined for 17 highly populated protein domains. A novel scoring method based on PCP-motifs that characterize known allergenic proteins wit

SUBMITTER: Lu W 

PROVIDER: S-EPMC5994374 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature