Internode length is reduced during myelination and remyelination by neurofilament medium phosphorylation in motor axons.

ABSTRACT: The distance between nodes of Ranvier, referred to as internode length, positively correlates with axon diameter, and is optimized during development to ensure maximal neuronal conduction velocity. Following myelin loss, internode length is reestablished through remyelination. However, remyelination results in short internode lengths and reduced conduction rates. We analyzed the potential role of neurofilament phosphorylation in regulating internode length during remyelination and myelination. Following ethidium bromide induced demyelination, levels of neurofilament medium (NF-M) and heavy (NF-H) phosphorylation were unaffected. Preventing NF-M lysine-serine-proline (KSP) repeat phosphorylation increased internode length by 30% after remyelination. To further analyze the role of NF-M phosp

SUBMITTER: Villalon E 

PROVIDER: S-EPMC5994378 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature