Ambient Size Distributions and Lung Deposition of Aerosol Dithiothreitol-Measured Oxidative Potential: Contrast between Soluble and Insoluble Particles.

ABSTRACT: Ambient particulate matter may upset redox homeostasis, leading to oxidative stress and adverse health effects. Size distributions of water-insoluble and water-soluble OP^DTT (dithiothreitol assay, measure of oxidative potential per air volume) are reported for a roadside site and an urban site. The average water-insoluble fractions were 23% and 51%, and 37% and 39%, for fine and coarse modes at the roadside and urban sites, respectively, measured during different periods. Water-soluble OP^DTT was unimodal, peaked near 1-2.5 μm due to contributions from fine-mode organic components plus coarse-mode transition metal ions. In contrast, water-insoluble OP^DTT was bimodal, with both fine and coarse modes. The main chemical components that drive both fractions appe

SUBMITTER: Fang T 

PROVIDER: S-EPMC5994611 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature