MS2PIP: a tool for MS/MS peak intensity prediction.

ABSTRACT:

Motivation

Tandem mass spectrometry provides the means to match mass spectrometry signal observations with the chemical entities that generated them. The technology produces signal spectra that contain information about the chemical dissociation pattern of a peptide that was forced to fragment using methods like collision-induced dissociation. The ability to predict these MS(2) signals and to understand this fragmentation process is important for sensitive high-throughput proteomics research.

Results

We present a new tool called MS(2)PIP for predicting the intensity of the most important fragment ion signal peaks from a peptide sequence. MS(2)PIP pre-processes a large dataset with confident peptide-to-spectrum matches to facilitate data-driven model induction using a random

SUBMITTER: Degroeve S 

PROVIDER: S-EPMC5994937 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature