DockAFM: benchmarking protein structures by docking under AFM topographs.

ABSTRACT:

Unlabelled

Proteins can adopt a variety of conformations. We present a simple server for scoring the agreement between 3D atomic structures and experimental envelopes obtained by atomic force microscopy. Three different structures of immunoglobulins (IgG) or blood coagulation factor V activated were tested and their agreement with several topographical surfaces was computed. This approach can be used to test structural variability within a family of proteins.

Availability and implementation

DockAFM is available at http://biodev.cea.fr/dockafm.

SUBMITTER: Chaves RC 

PROVIDER: S-EPMC5994945 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature