Fuzzy optimization for detecting enzyme targets of human uric acid metabolism.

ABSTRACT:

Motivation

Mathematical modeling and optimization have been used for detecting enzyme targets in human metabolic disorders. Such optimal drug design methods are generally differentiated as two stages, identification and decision-making, to find optimal targets. We developed a unified method named fuzzy equal metabolic adjustment to formulate an optimal enzyme target design problem for drug discovery. The optimization framework combines the identification of enzyme targets and a decision-making strategy simultaneously. The objectives of this algorithm include evaluations of the therapeutic effect of target enzymes, the adverse effects of drugs and the minimum effective dose (MED).

Results

An existing generalized mass action system model of human uric acid (UA) metabolism was

SUBMITTER: Hsu KC 

PROVIDER: S-EPMC5994946 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature