Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a⁺ CD4⁺ T Cells From Early HIV Infection to Effective cART.

ABSTRACT: CD32a has been proposed as a specific marker of latently HIV-infected CD4⁺ T cells. However, CD32a was recently found to be expressed on CD4⁺ T cells of healthy donors, leading to controversy on the relevance of this marker in HIV persistence. Here, we used mass cytometry to characterize the landscape and variation in the abundance of CD32a⁺ CD4⁺ T cells during HIV infection. To this end, we analyzed CD32a⁺ CD4⁺ T cells in primary HIV infection before and after effective combination antiretroviral therapy (cART) and in healthy donors. We found that CD32a⁺ CD4⁺ T cells include heterogeneous subsets that are differentially affected by HIV infection. Our analysis revealed that naive (_N), central

SUBMITTER: Coindre S 

PROVIDER: S-EPMC5995043 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature