Uridine 5'-diphospho-glucronosyltrasferase: Its role in pharmacogenomics and human disease.

ABSTRACT: Biotransformation is an enzyme-catalyzed process in which the body converts endogenous compounds, xenobiotics and toxic substances into harmless or easily excreted metabolites. The biotransformation reactions are classified as phase I and II reactions. Uridine 5'-diphospho (UDP)-glucuronosyltransferases (UGTs) are a superfamily of phase II enzymes which have roles in the conjugation of xenobiotics or endogenous compounds, including drugs and bilirubin, with glucuronic acid to make them easier to excrete. The method the human body uses to achieve glucuronidation may be affected by a large interindividual variation due to changes in the sequences of the genes encoding these enzymes. In the last five years, the study of the genetic variants of the UGTs at a molecular level has become importan

SUBMITTER: Sanchez-Dominguez CN 

PROVIDER: S-EPMC5995049 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature