Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts.

ABSTRACT:

Objective

The purpose of this study was to validate our previous genetic association findings related to the endoglin (ENG) pathway from an American Caucasian preeclampsia cohort in independent preeclampsia cohorts. We also sought to explore the ENG pathway for new genetic associations in these independent cohorts.

Study design

We used a tagging single nucleotide (tSNP) approach to assess genetic variability across five ENG pathway genes (ENG, TGFβ1, TGFβR1, ALK1, and TGFβR2) in a Caucasian cohort from Norway (n = 77 preeclampsia cases & n = 63 normotensive controls) and a White Hispanic cohort from Southern California (n = 69 preeclampsia cases & n = 106 normotensive controls).

Main outcome measures

Univariate analyses (Chi Square, Fisher's Exact) and multivariate lo

SUBMITTER: Schmella MJ 

PROVIDER: S-EPMC5995147 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature