Biomarkers for the risk of thrombosis in pancreatic adenocarcinoma are related to cancer process.

ABSTRACT:

Background

Venous thrombo-embolic events (VTE) frequently occur in patients with pancreatic ductal adenocarcinoma (PDAC) and contribute to high morbidity and mortality.

Objectives

To determine whether VTE biomarkers are related to cancer, inflammation or precancerous states and to assess their relevance to predict VTE in PDAC.

Patients and methods

We compared VTE biomarkers in patients with PDAC (n = 42), intraductal papillary mucinous neoplasm of the pancreas (IPMN, n = 48) or chronic pancreatitis (n = 50). PDAC patients were followed-up for 6 months.

Results

Factor VIII, D-dimers, von Willebrand factor, free tissue factor pathway inhibitor and microvesicle-tissue factor (MV-TF) activity were higher in PDAC patients compared to patients wi

SUBMITTER: Faille D 

PROVIDER: S-EPMC5995170 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature