Revising the Structural Diversity of Ribosomal Proteins Across the Three Domains of Life.

ABSTRACT: Ribosomal proteins are indispensable components of a living cell, and yet their structures are remarkably diverse in different species. Here we use manually curated structural alignments to provide a comprehensive catalog of structural variations in homologous ribosomal proteins from bacteria, archaea, eukaryotes, and eukaryotic organelles. By resolving numerous ambiguities and errors of automated structural and sequence alignments, we uncover a whole new class of structural variations that reside within seemingly conserved segments of ribosomal proteins. We then illustrate that these variations reflect an apparent adaptation of ribosomal proteins to the specific environments and lifestyles of living species. Finally, we show that most of these structural variations reside within nonglobul

SUBMITTER: Melnikov S 

PROVIDER: S-EPMC5995209 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature