Development of a preclinical humanized mouse model to evaluate acute toxicity of an influenza vaccine.

ABSTRACT: Safety evaluation of a human vaccine is critical for vaccine development and for preventing an unexpected adverse reaction in humans. Nonetheless, to date, very few systems have been described for preclinical studies of human adverse reactions in vivo. Previously, we have identified biomarker genes expressed in the lungs for evaluation of influenza vaccine safety, and their usefulness in rodent models and for adjuvant-containing vaccines has already been reported. Here, our purpose was to develop a novel humanized mouse model retaining human innate-immunity-related cells to assess the safety of influenza vaccines using the previously identified biomarker genes. In the present study, we tested whether the two humanized models, a short-term and long-term reconstitution model of NOD/Sh

SUBMITTER: Sasaki E 

PROVIDER: S-EPMC5995229 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature