Association of mRNA expression of iron metabolism-associated genes and progression of non-alcoholic steatohepatitis in rats.

ABSTRACT:

Background

Excess iron is associated with non-alcoholic steatohepatitis (NASH).

Results

mRNA expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, hepcidin, hephaestin and transferrin receptor 1 in liver were higher in high fat, high cholesterol-containing diet (HFCD) group than in normal diet (ND) group. mRNA levels of divalent metal transporter 1 and transferrin receptor 1, which stimulate iron absorption and excretion, were enhanced in small intestine. Epithelial mucosa of small intestine in HFCD group was characterized by plasma cell and eosinophil infiltration and increased vacuoles. Iron absorption was enhanced in this NASH model in the context of chronic inflammation of small intestinal epithelial cells, consequences of intestinal epithelia

SUBMITTER: Higuchi T 

PROVIDER: S-EPMC5995254 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature