Targeted DNA sequencing of non-small cell lung cancer identifies mutations associated with brain metastases.

ABSTRACT:

Introduction

This study explores the hypothesis that dominant molecular oncogenes in non-small cell lung cancer (NSCLC) are associated with metastatic spread to the brain.

Methods

NSCLC patient groups with no evidence of metastasis, with metastatic disease to a non-CNS site, who developed brain metastasis after diagnosis, and patients with simultaneous diagnosis of NSCLC and metastatic brain lesions were studied using targeted sequencing.

Results

In patients with brain metastasis versus those without, only 2 variants (one each in BCL6 and NOTHC2) were identified that occurred in ≥ 4 NSCLC of patients with brain metastases but ≤ 1 of the NSCLC samples without brain metastases. At the gene level, 20 genes were found to have unique variants in more than 33% of the patien

SUBMITTER: Wilson GD 

PROVIDER: S-EPMC5995256 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature