GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity.

ABSTRACT:

Purpose

Adenomyosis has a negative impact on female fertility. GnRH agonist treatment can improve pregnancy outcomes in women with adenomyosis. However, the impact of GnRH agonist upon endometrium receptivity of patients with adenomyosis remains unclear. In this study, endometrial receptivity and pregnancy outcome were investigated using a mouse model of adenomyosis.

Materials and methods

Adenomyosis was induced in 12 female ICR mice, neonatally treated with tamoxifen, while another six female mice (control group) received solvent only. At 75 days, the induced adenomyosis group was randomly divided into two groups: an untreated group and a group treated with GnRH agonist (n = 6 each). Sixty days later, the mice were mated and pregnancy outcomes were observed and compared amo

SUBMITTER: Guo S 

PROVIDER: S-EPMC5995291 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature