Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies.

ABSTRACT:

Introduction

Accumulating epidemiological evidence points to strong genetic susceptibility to placental abruption (PA). However, characterization of genes associated with PA remains incomplete. We conducted a genome-wide association study (GWAS) of PA and a meta-analysis of GWAS.

Methods

Participants of the Placental Abruption Genetic Epidemiology (PAGE) study, a population based case-control study of PA conducted in Lima, Peru, were genotyped using the Illumina HumanCore-24 BeadChip platform. Genotypes were imputed using the 1000 genomes reference panel, and >4.9 million SNPs that passed quality control were analyzed. We performed a GWAS in PAGE participants (507 PA cases and 1090 controls) and a GWAS meta-analysis in 2512 participants (959 PA cases and 1553 controls) that

SUBMITTER: Workalemahu T 

PROVIDER: S-EPMC5995331 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature